Jennifer Güler and Steven R. Caliari
Jennifer Güler and Steven R. Caliari are the most recent UVA faculty to receive an NSF CAREER award. Guler, an Assistant Professor of Biology, received an award for her project: A paired experimental-computational approach to elucidate stress responses in early-branching eukaryotes. Caliari, an Assistant Professor of Chemical Engineering and Biomedical Engineering, received an award for his project: Mechanically dynamic and viscoelastic hydrogels as tools for studying fibroblast epigenetic memory.
Research in the Güler Malaria Lab focuses on the human-infective malaria parasite, Plasmodium falciparum. Some projects are described below:
- Research on the underlying mechanisms that drive genetic change in parasites during the development of antimalarial resistance. Our studies in this area utilize a range of cellular, biochemical and molecular techniques to uncover pathways that are important for this process.
- Some genetic alterations that arise during antimalarial exposure drive metabolic adaptation in the parasite. By employing metabolite profiling paired with computational modeling to investigate these slight adjustments, we aim to reveal unique pathways that enhance parasite survival.
- Partnering with researchers in malaria endemic countries to apply our predictions from lab-based models to investigations with patient-isolated parasites. These studies inform our knowledge of general parasite adaptation and its effect on disease severity.
For more information, please visit the Güler Malaria Lab Website.
Caliari's lab designs, synthesizes, and characterizes new biomaterials to explore the dynamic interplay between cells and their microenvironment, applying these platforms to address fundamental human health challenges in understanding disease and engineering tissues. In addition to the NSF CAREER award, Steven has recently received the NIH (NIGMS) Maximizing Investigators’ Research Award (MIRA). His lab is grateful for generous support from the NIH, DoD, NSF, V Foundation, and UVA-Coulter Translational Research Partnership.
For more information, please visit Steven R. Caliari's webpage.